Customer story

Reducing inflammation and preventing health-to-disease transition in treatment of arthritis

"The help of Spinverse was invaluable in the preparation of the grant application. Spinverse helped with creating the budget, with feeding the text into the system and in creating figures and finalizing the text. They truly wanted the application to succeed and worked very hard to achieve this goal."

Kari Eklund, Professor, Helsinki University Hospital (HUS).

Customer story in numbers

7

MILLION €

4

YEARS

12

PARTNERS

7

COUNTRIES

Funding instrument

Horizon Europe

Rheumatic diseases affect more than 40% of Europe's population and cause significant disability, pain, reduced lifespan and a very high economic burden. The ENDOTARGET consortium project, led by Helsinki University Hospital (HUS), explores the role of chronic systemic inflammation as a driver in the transition from health to disease. The project participants will study immunologically active compounds derived from intestinal microbiota. 

Key challenges

Rheumatic diseases affect more than 40% of Europe's population and cause significant disability, pain, reduced lifespan and a very high economic burden. The ENDOTARGET consortium project, led by Helsinki University Hospital (HUS), explores the role of chronic systemic inflammation as a driver in the transition from health to disease. The project participants will study immunologically active compounds derived from intestinal microbiota. 

How we reached the goals

Spinverse experts provided their expertise on the complex funding process, concept development and consortium building to secure the successful outcome of the proposal.

Key takeaways

ENDOTARGET aims to explore the relationship between gut microbiota, intestinal permeability, and systemic endotoxemia. Further it aims to understand their role as drivers of disease onset and disease activity in rheumatoid arthritis, osteoarthritis and spondyloarthritis. The findings of the four-year research consortium may lead to the identification and development of novel preventive and therapeutic approaches.

Impact of the project

Social impact: Significant impact on the lives of patients suffering from rheumatic diseases: the project aims to predict and prevent the health-to-disease transition of individuals.